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Fig. 1. Schematic model of NMDA receptor binding sites. Schematic model of the NMDA receptor shows hypothesized binding sites for agonist, glutamate (Glu), and modulators glycine (Gly), Zn2+, Ca2+, Mg2+, phencyclidine (PCP), and other dissociative anesthetics, and H+. Phosphorylation consensus sequences are present on the intracellular surface of the receptor. Thiol groups in close proximity on the receptor are thought to constitute the redox modulatory site. Steroids bind to at least two distinct sites and potentiate or inhibit NMDA receptor function.

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