Role of the p Subunit

Whole-cell voltage-clamp and single channel recording techniques applied to human embryonic kidney cells (HEK-293) demonstrated both the GABA-modulatory and GABA-mimetic actions of 3a,5a-THPROG and 3a,5a-THDOC to be preserved in cells transfected with a1P1y2L,a1P1, or p1 subunits (33). Hence, the steroid site is even represented on the homo-oligomeric (P1 subunit). The GABA-modulatory and GABA-mimetic actions of the anticonvulsant loreclezole (34) and the general anesthetic etomidate

Table 1

The Influence of the Subunit Composition of the GABAa Receptor on the GABA-Modulatory Effects of 3a-Hydroxy-5a-Pregnan-20-One and 5a-Pregnan-3a,20a-Diol

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