P450 Nomenclature

In 1987, the use of trivial names for P450 enzymes was replaced by a more systematic nomenclature (34). P450s were classified, on the basis of their amino-acid sequence similarities, into families (40% sequence similarity) and subfamilies (55% sequence similarity). In mammals, families 1-4 are xenobiotic, fatty acid, and steroid hydroxylases (Table 1). Families 5, 7, 11, 17, 19, 21, 24, 27, and 51 are biosynthetic enzymes involved in the synthesis of thromboxane, bile acids, steroid hormones, and cholesterol (Table 2). The latest update (35) reveals that there are 14 families and 26 subfamilies in mammals.

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