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( 1 + [ACh]/K> ( 1 + [P[/K»'\ \1 + [ACh]/K/ \1 + [P]/K v

where: A, the fraction of receptors in the open state; L = the equilibrium constant in absence of an agonist, Ka, Kb, Ka',and Kb = the respective microscopic dissociation constants for the agonist and allosteric effector, and [ACh] = the agonist concentration and [P] = the effector concentration. Constants n and m correspond to the number of allosteric sites for the ligand and the effector, respectively.

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