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Fig. 5. Effects of 1 mg PREG on EEG power spectra for the four sleep cycles in healthy adult males. Bars show deviations in percent from the placebo condition as depicted by the zero reference line (mean ± SEM). Solid bars indicate significant differences from the placebo condition (p < 0.05). (Adapted with permission from ref. 36.)

tion of DHEA (40), which is compatible with a potential memory enhancing effect in humans. Moreover, DHEA administration resulted in an increase in EEG activity in the sigma frequency range during REM sleep (40) (Fig. 6). Thus, unlike PREG, DHEA

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