Induction of Brain P450

Although constitutive forms have proven to be elusive, the level of cytochrome P450 in the rat brain can be increased 2-7 fold by exposure of rats to ethanol, organic solvents, and certain neuroactive drugs. After such treatment, multiple forms can be identified in the brain.

Table 3

P450 Isoforms Involved in Testosterone Metabolism in the Rat Brain3

Table 3

P450 Isoforms Involved in Testosterone Metabolism in the Rat Brain3

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