G

GABAa receptor, 14

alpha subunits, 128, 129 beta subunits, 127, 128 CI7 side chain, 131 C3 substitution, 130, 13 1 C20 substitution, 132 C21 substitution, 132, 133 delta subunits, 129, 130 epsilon subunits, 129, 130 gamma subunits, 129 modulator properties, 35 I f multiple steroid-binding sites, 144 neurosteroid antagonists, 155 -157 neurosteroids interaction, 125-138 ring system, 130

structure activity relationship, 130-135 water soluble steroids, 133 135 GABA/BZD receptor-chloride ionophore complex DHEA, 318 PREG, 318 GABAergic neurotransmission steroid potentiation, 143 150 GABAergic steroids diastereomeric selectivity, 143 -145 enantiomeric selectivity, 145 147 parturition, 162 structures, 146f GABA receptor

NMDA receptor, 343 Gamma-aminobutyric acid A (GABAa), 5 NMDA receptors, 177 nongenomic and genomic properties, 350-354

vs. PBRs, 76 Gamma-aminobutyric acid (GABA) antagonistic steroids physiological role, 157-162 serotonergic system, 237 Gamma amino butyric/benzodiazepine

(GABA/BZD) receptor-chloride iono-phorc complex neurosteroids, 317, 3 18 Gas chromatographic-mass fragmentographic method allopregnolone measurement, 5 Genomic actions estrogen, 238 Glial cells neurosteroids trophic effect, 16-19 steroid hormones effects, 17 Glial fibrillary acidic protein (GFAP) estradiol, 256, 258, 259 PREG, 256-257 testosterone, 256 Glueocoritcosteroids, 207 Glutumate receptors. 14 endogenous modulators neurosteroids, 181, 182 ionotropic, 136, 137

neuroaetive steroid modulation, 167— 185 recombinant modulation, 18 Of Glycine receptors, 135, 136 Gonadal hormone action hypothalamus, 234, 235 IGF-1, 259, 260 regulation brain synaptic plasticity, 233-244 Gonadogenesis, 69 Growth factors role. 243 steroids brain, 259-263 Guanine nucleotide proteins role, 229. 230

Anxiety and Depression 101

Anxiety and Depression 101

Everything you ever wanted to know about. We have been discussing depression and anxiety and how different information that is out on the market only seems to target one particular cure for these two common conditions that seem to walk hand in hand.

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