Besides reducing seizure thresholds and enhancing LTP in hippocampus, estradiol treatment is reported to exert effects on hippocampal-dependent learning and memory.
Fig. 1. This model of synaptogenesis in the hippocampus emphasizes the role of NMDA receptors and the possible role of afferents from the entorhinal cortex and serotonin input, as well as the possible role of the interneurons in which the estrogen receptors have been found.
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