Contents

Preface v

Contributors ix

List of Main Steroids and Enzymes Involved in Steroid Metabolism xiii

1 Neurosteroids: From Definition and Biochemistry to

Physiopathologic Function 1

Paul Robel, Michael Schumacher, and Etienne-Emile Baulieu

2 Molecular Biology and Developmental Regulation of the

Enzymes Involved in the Biosynthesis and Metabolism of Neurosteroids 27

Synthia H. Mellon and Nathalie A. Compagnone

3 Cytochrome P450 in the Central Nervous System 51

Margaret Warner and Jan-Àke Gustafsson

4 Steroidogenic Factor 1 Plays Key Roles in Adrenal and

Gonadal Development and in Endocrine Function 67

Kathleen M. Caron, Yayoi Ikeda, Xunrong Luo, and Keith L. Parker

5 Peripheral-Type Benzodiazepine Receptor: Role in the

Regulation of Steroid and Neurosteroid Biosynthesis 75

Caterina Cascio, Patrizia Guarneri, Hua Li, Rachel C. Brown,

Hakima Amri, Noureddine Boujrad, Maria Kotoula, Branislav Vidic, Katy Drieu, and Vassilios Papadopoulos

6 Aspects of Hormonal Steroid Metabolism in the

Nervous System 97

Angelo Poletti, Fabio Celotti, Roberto Maggi,

Roberto C. Melcangi, Luciano Martini, and Paola Negri-Cesi

7 The Selective Interaction of Neurosteroids with the GABAa

Receptor 125

Jeremy J. Lambert, Delia Belelli, Susan E. Shepherd, Marco Pistis, and John A. Peters

8 Potentiation of GABAergic Neurotransmission by Steroids 143

Robert H. Purdy and Steven M. Paul

9 Neurosteroid Antagonists of the GABAa Receptors 155

Maria Dorota Majewska

10 Modulation of Ionotropic Glutamate Receptors by Neuroactive

Steroids 167

Terrell T. Gibbs, Nader Yaghoubi, Charles E. Weaver, Jr.,

Mijeong Park-Chung, Shelley J. Russek, and David H. Farb

11 Steroidal Modulation of Sigma Receptor Function 191

Stéphane Bastianetto, François Monnet, Jean-Louis Junien, and Rémi Quirion

12 Steroid Modulation of the Nicotinic Acetylcholine Receptor 207

Bruno Buisson and Daniel Bertrand

13 Neuroactive Steroid Modulation of Neuronal Voltage-Gated

Calcium Channels 225

Jarlath M. H. ffrench-Mullen

14 Gonadal Hormone Regulation of Synaptic Plasticity in the Brain: What Is the Mechanism? 233

Bruce S. McEwen

15 Steroid Effects on Brain Plasticity: Role of Glial Cells and

Trophic Factors 255

Luis Miguel Garcia-Segura, Julie Ann Chowen,

Frederick Naftolin, and Ignacio Torres-Aleman

16 Steroid Receptors in Brain Cell Membranes 269

Victor D. Ramírez and Jianbiao Zheng

17 Novel Mechanisms of Estrogen Action in the Developing

Brain: Role of Steroid/Neurotrophin Interactions 293

C. Dominique Toran-Allerand

18 Neurosteroids: Behavioral Studies 317

Willy Mayo, Monique Vallée, Muriel Darnaudéry, and Michel Le Moal

19 Remarkable Memory-Enhancing Effects of Pregnenolone

Sulfate with Pheromone-Like Sensitivity: An Amplificatory

Hypothesis 337

Eugene Roberts

20 The Neuropsychopharmacological Potential of Neurosteroids ... 349 Rainer Rupprecht, Elisabeth Friess, and Florian Holsboer

Index 365

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