A

Acetylcholine (ACh), 210 Acetylcholine receptor, 208 Acetyltransferase, 12-13 Active avoidance DHEAS, 326-327 PREG, 326-327 PREGS, 327 Acute ethanol intoxication neurosteroid levels, 6—7 Adenine nucleotide carrier (ADC), 77, 78 Adhesion molecules astroglia signaling steroids, 258, 259 Adrenodoxin, 33 Adrenodoxin reductase, 33 Adulthood P450aro sex steroid regulation, 104 Affective disorders neuroactive steroids, 149 Afferent system midbrain serotonergic system, 237 Aggressive behavior DHEA, 323 neurosteroids, 160, 161 PREGS, 323 Aging neurosteroids, 159, 160

stress and anxiety, 323, 324 Alcohol dependence neuroactive steroids, 147—149 Alcohol withdrawal neuroactive steroids, 147—149 Aldosterone synthase, 54t, 57, 58 Allopregnanolone aged animals, 324 burying behavior, 321 elevated plus maze, 318 GABA/BZD receptor-chloride ionophore complex, 317, 318 infant animals, 323, 324 light-dark transition chamber, 319

metabolic pathways, 15Of mirror-chamber test, 320 operant conflict tests, 321 passive avoidance, 326 structures, 145f swim-stress paradigm, 322, 323 Allopregnolone measurement gas chromatographic-mass fragmentographic method, 5 radioimmunoassay, 5 Allosteric model predictions, 217f schematic diagram, 217f Allosteric modulation ligand-gated channels, 215-217 Alphaxalone analysis, 126 Alzheimer's disease, 114 AmER

estradiol-evoked dopamine release female rat striatal tissue, 270-274 Androgen dihydrotestosterone (DHT)

testosterone, 41 Androgens, 207 Androgens aromatization, 1, 2 Anti-estrogens, 238 Anxiety allopregnanolone, 318-321 DHEAS, 320

neurosteroid expression, 322, 323 neurosteroids age-related effects, 323, 324 PREG, 319 PREGS, 320 PROG, 318, 320, 321 Anxiety-like measurement paradigms, 318-322 burying behavior, 321 elevated plus maze, 318, 319 light-dark transition chamber, 319 mirror-chamber test, 319, 320 operant conflict tests, 32 Approach-based paradigms, 328-330

nonspatial food/water reinforced tasks, 329, 330

spatial food/water-search tasks, 328, 329 Arachidonic acid, 56 Aromatase, 59 Astrocytes neurosteroids trophic effect, 16, 17 Astroglia hormonal steroids, 256-259 IGF -1 receptors estradiol, 261 PREG

brain injury. 257 PROG, 256 257 brain injury, 257 synaptic remodeling, 258 sex steroids, 258 steroids

IGF-1, 262-263 Astroglial cells involvement, 243 Astroglia plasticity steroid modulation after brain injury. 257, 258 Astroglia signaling adhesion molecules steroids, 258 259

Avoidance, 326 327

Avoidance-based paradigms, 325—328 active avoidance, 326, 327 passive avoidance, 325, 326 water maze, 327

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