Bio Ontologies Data Models Nomenclature

5.6.1 Linking to downstream biological validation 187

5.6.2 Problems in determining the results 187

Chapter 6: From Functional Genomics to Clinical Relevance—Getting the Phenotype Right 189

6.1 Electronic Medical Records 189

6.2 Standardized Vocabularies for Clinical Phenotypes 190

6.3 Privacy of Clinical Data 191

6.3.1 Anonymization 192

6.3.2 Privacy rules 193

6.4 Costs of Clinical Data Acquisition 193

Chapter 7: The Near Future 195

Overview 195

7.1 New Methods for Gene Expression Profiling 195

7.1.1 Electronic positioning of molecules: Nanogen 197

7.1.2 Ink-jet spotting of arrays: Agilent 198

7.1.3 Coded microbeads bound to oligonucleotides: Illumina 199

7.1.4 Serial Analysis of Gene Expression (SAGE) 201

7.1.5 Parallel signature sequencing on microbead arrays: Lynx 203

7.1.6 Gel pad technology: Motorola 203

7.2 Respecting the Older Generation 203

7.2.1 The generation gap 204

7.2.2 Separating the wheat from the chaff 205

7.2.3 A persistent problem 206

7.3 Selecting Software 206

7.4 Investing in the Future of the Genomic Enterprise 209

Glossary 211

A 211

B 211

C 212

D 212

E 212

F 213

G 213

H 213

1 214

M 214

N 214

0 214

P 215

S 216

T 216

References 217

List of Figures 227

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