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ISK would like to thank his two co-authors: Without their belief in the worth of this collaborative enterprise and without their expertise, this book would never have been completed. Dozens of colleagues generously provided of their knowledge and resources including Hamish Fraser, Steven Greenberg, Winston Kuo, Ashish Nimgaonkar, Peter Park, Marco Ramoni, Alberto Riva, Ben Reis, Zoltan Szallasi, Peter Szolovits, and Christine Tsien. Our colleagues in industry, notably Bill Craumer, John Hart, and Bill Buffington were equally generous. Of course, all errors and mis-interpretations remain the authors'. David Ruckle is due thanks for his effective transmogrification of the authors' scribbles into attractive illustrations. To Marie Boyle, ISK offers his gratitude for her unparalleled organization skills. Robert Prior would do any publisher proud for his thoughtfulness and integrity. Elaine and Leo provided a quiet and hospitable haven for ISK before some particularly tight deadlines. To Heidi, ISK is thankful for the love, understanding and encouragement that enabled this work to proceed even when sunny days, and other enticing distractions beckoned. Finally, to Judith and the late Akiva Kohane who transmitted the core values of which this effort is a small reflection, ISK will always be in their debt.

ISK's time on this project has been funded in part through the generosity of the John F. and Virginia B. Taplin Award of the Harvard-MIT Division of Health Sciences and Technology as well through funding by the NIH including N01 LM-9-3536 "Personal Internetworked Notary and Guardian" from the National Library of medicine, HL066582-01 and HL-99-24 through the Program for Genomic Applications of the National Heart Lung and Blood Institute, U24 DK058739 "NIDDK Biotechnology Center" by the National Institute of Diabetes, Digestive and Kidney Diseases, 1R21 NS41764-01 "Functional Genomic Analysis of the Developing Cerebellum" by the National Institute of Neurological Disorders and Stroke, U01 CA091429-01 "Shared Pathology Informatics Network" of the National Cancer Institute, and P01 NS 40828-01 "Gene Expression in Normal and Diseased Muscle During Development" by the National Institute of Neurological Disorders and Stroke.

ATK is deeply indebted to his co-authors for their immense patience and learning in answering and enduring his oftentimes naive biologic queries; To them and Marie Boyle, our work-besieged CHIP administrator, for their unrelenting cheerfulness and easy camaraderie during our writing spells. ATK is very grateful to David Rowitch for funding support via the National Institutes of Health grant 1R21 NS041764-01 "Functional Genomic Analysis of the Developing Cerebellum" throughout the duration of this project. Lastly, but not in the least, he expresses his deep gratitude to his parents Kwang Khoon and Rose Kho for their ever constant love and affection.

AJB is first indebted to his co-authors for the stimulating discussions needed to prepare this book, many of which have resulted in the design and development of novel bioinformatics methods while this book was being written. In addition, without Marie Boyle, this book would never have been written or organized. AJB wishes to thank his friend and mentor, Dr. Isaac Kohane, for accepting him into the Children's Hospital Informatics Program four years ago. AJB sincerely owes his being in this field of research to Dr. Kohane's early vision and strong collaborative connections to biologists. AJB appreciates Dr. Kohane's continued support and development of his career in bioinformatics. AJB also wishes to thank his division chief, Dr. Joseph Majzoub, for his support of AJB's clinical and research environment, and Professor Peter Szolovits for his guidance and advice. AJB remembers his uncle, the late Dr. Prakash Kulkarni, who inspired him to become a pediatrician, and also thanks Dr. Simeon Taylor and Dr. Michael Quon, both of whom taught AJB everything he knows about the laboratory study of molecular biology and inspired him to enter the field of endocrinology. AJB wishes to thank his brother, Dr. Manish Butte, for being a role model with his academic pursuits and his discussions on the nature of biophysics and bioinformatics, and his parents Janardhan and Mangala Butte, for their love, support, and wisdom in exposing their children to computers at an early age. Finally, AJB wishes to thank his wife, Dr. Tarangini Deshpande, for her love, support, and her encouragement to complete this work.

During the writing of this work, AJB has been funded by and wishes to thank the Endocrine Fellows Foundation, the Genentech Center for Clinical Research and Education, the Lawson Wilkins Pediatric Endocrinology Society, the Harvard Center for Neurodegenerative Research, and the Merck-Massachusetts Institute of Technology partnership. AJB was also supported in part by the grant "Genomics of Cardiovascular Development, Adaptation, and Remodeling" funded by the National Heart Lung and Blood Institute's Program in Genomic Applications, U01 HL066582, the grant "Harvard-MIT-NEMC Research Training in Health Informatics", funded by the National Library of Medicine, 5T15 LM07092, and the grant "NIDDK Biotechnology Center", funded by the

National Institute of Diabetes, Digestive and Kidney Diseases, U24 DK058739.

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Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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