where FACTOR is the safety or uncertainty factor = 100. So far, this factor has proved to be successful in protecting consumers.

The 100 factor is obtained from two factors: 10 to extrapolate animal data to human conditions (i.e., a factor considering differences between two species) and 10 to consider metabolic variation among humans (i.e., within a species). Thus, the safety factor is the mathematical product of these two factors:

' Factor of |

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