Beneficial Effects of Tannins



Japanese individuals

Topical application on mouse skin

Oral application on mice skin tumor formation

Oral supplementation of tannic acid on mice forestomach and pulmonary tumors DNA protection assay with ellagic acid


Tannic acid in the Ames assay


Tannic acid against Meulius lacrymans and Penicillium species

Condensed tannins against Botrytis cinerea Inhibition

Tannins Bacteriostatic and/or bactericidal against Staphylococcus aureus, Streptococcus pneumoniae, Bacillus anthracis, Shigella dysenteriae, and Salmonella senftenberg, among others

Purified tannins against cariogenic bacteria Streptococcus mutans and S. sobrinus are inhibited by condensed tannins

Source: Adapted from Chung et al. (1998).46

lipid peroxidation by xenobiotics, through generation of a free radical species that induces alteration of cellular functions, genotoxic damage, and tumor initiation. They inhibit cytochrome P-450 mixed function oxygenases, enhance phase II enzymes glutathione-S-transferase and quinone reductase, and enhance the antiox-idant enzymes glutathione peroxidase and catalase. In summary, tannins present in varying concentration in foods may have profound effects on human health.46

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