Genotoxicity Studies

Although patulin failed to show mutagenicity in the Ames test and other bacteria-based assays, it has been shown to produce chromosomal damage in mammalian systems [9,10,40]. Patulin was shown to be potent inducer of chromatid-type aberrations to Chinese hamster V79E cells, but did not increase sister-chromatic exchange (SCE) frequency. In contrast, Liu et al. [46] reported that patulin caused a significant dose-dependent increase in SCE frequency in both Chinese hamster ovary cells and human lymphocytes. Induction of chromosome damage and micronuclei formation in mammalian cells suggest a possible clastogenic property of patulin [46]. Nucleic acid synthesis and protein synthesis have also been reported to be inhibited by patulin [47,48].

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