Acute Toxicity Studies

In acute toxicity studies with a variety of experimental animals, the LD50 values for patulin, as well as the lesions observed, varied [41]. Overall, patulin produced lesions to the gastrointestinal tract, including epithelial degeneration, hemorrhaging, and ulceration of the gastric mucosa [41-43]. Other lesions included edema of the lungs and brain, visceral organ congestion, and hepatic and renal necrosis [44]. The oral LD50 in rats, mice, and hamsters has been reported in the range 30 to 48mg/kg body weight [41].

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