In acute toxicity studies with a variety of experimental animals, the LD50 values for patulin, as well as the lesions observed, varied . Overall, patulin produced lesions to the gastrointestinal tract, including epithelial degeneration, hemorrhaging, and ulceration of the gastric mucosa [41-43]. Other lesions included edema of the lungs and brain, visceral organ congestion, and hepatic and renal necrosis . The oral LD50 in rats, mice, and hamsters has been reported in the range 30 to 48mg/kg body weight .
Was this article helpful?