Zebrafish A Model for Studying Microvascular Development and Function

Kameha Kidd and Brant Weinstein

Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health,

Bethesda, Maryland

The zebrafish is a relatively recent addition to the field of microvascular research, but it possesses a number of distinct advantages for studies of blood vessel formation in vivo including experimental and genetic accessibility and an optically clear embryo. Because of its useful attributes, the fish has already begun to contribute significantly to our understanding of key factors involved in vessel growth, differentiation, and maturation, as well as the mechanisms that guide the patterning and function of the vasculature. In this chapter we provide a historical background and brief overview of the use of the fish for studies of blood vessel formation.

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Essentials of Human Physiology

Essentials of Human Physiology

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