As noted in Section I, larger arterioles are located anatomically in a "pair" with larger collecting venules. This raises the possibility that control mechanisms may be coupled from these outflow venules to their neighboring arteri-oles—an attractive idea that conceptualizes how changes in venous outflow due to changes in metabolism could be coupled back locally within the tissue to change inflow capacity. The idea that venous Po2 may be sensed in this way by inflow arterioles has been raised repeatedly for many decades. In recent years, veno-arteriolar coupling of responses to metabolites such as adenosine has been clearly demonstrated, indicating that this means of communication within the muscle has the capacity to modify inflow to the tissue in a way that, at least conceptually, should serve to match blood flow to metabolism more closely.
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This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.