Using EPCs to impede vascular growth is also being investigated. Ferrari and colleagues used bone marrow-derived cells to deliver a conditional cytotoxic gene to tumor vasculature. This approach resulted in a significant decrease in tumor growth. Other laboratories have used similar methods to impede tumor growth. The depletion of circulating endothelial progenitors is also being studied as an approach for the treatment of cancer. Preclinical experiments demonstrated the necessity of endothelial progenitors in tumor growth, and low-dose chemotherapy has been shown to decrease the number of circulating endothelial precursors. This treatment strategy is currently being evaluated in clinical trials.
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This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.