Three Pore Theory

Three-pore theory explains water and solute transport across the peritoneal microvessel during peritoneal dialysis. For this transport process, there are three kinds of pores: a large number of small pores (radius 40 to 50 Â) for low molecular weight, a very low number of large pores (radius 250 Â) for macromolecules, and ultrasmall pores (radius 3 to 5Â) for water transport but rejecting the transfer of solutes. Aquaporins, especially aquaporin-1, which was identified recently, are the proteins constituting these transendothelial water channels; they are assumed to be ultrasmall pores.

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