It can fairly be argued that the microvasculature of the endometrium is the essential functional, as opposed to merely supportive, unit of this organ. While it certainly supports the epithelial cells and stromal fibroblasts, it also plays a special and essential role by generating extraordinary amounts of interstitial fluid at specific times—fluid that is absolutely essential for the rapid tissue repair, growth, and differentiation that prepare the endometrium to receive a fertilized egg. Capillaries also are an integral functional component of the endometrial glands, secretions of which nourish and protect the early embryo. Finally, they supply oxygen and nutrients and remove wastes for the invading, growing conceptus in early pregnancy. When they are no longer adequate for this task, the placental cells themselves take over by invading the vessels and forming low-resistance channels that open directly onto the surface of the placenta, bathing it in maternal blood. Rapid progress is being made in understanding the factors that control these complex developmental events, but much remains to be learned. Further research could reveal much about the basic mechanisms that regulate new blood vessel growth, its cessation, and vessel regression in general, knowledge that could be important for understanding and developing new treatments for several uterine pathologies as well as the angiogenesis that plays an essential role in tumor growth and numerous other diseases.
Endometrium: The lining of the uterus that consists of the function-alis layer (lumenal surface epithelium, stroma, and glands) and the basalis layer, which is adjacent to the myometrium (the external muscular layer of the uterus) and from which a new functionalis is regenerated during each menstrual cycle.
Estrogen: The steroid hormone produced cyclically by the ovary that stimulates growth of the uterine endometrium and initiates implantation (in part, via induction of VEGF expression).
Glands: Epithelial cell-lined invaginations that extend from the uterine lumen deep into the functionalis and secrete nutrients and other sub stances essential for the survival, implantation, and early development of the embryo.
Spiral arteries: The major feed arteries that extend from the basalis to near the lumenal surface epithelium of the functionalis layer and give rise to the capillary networks that surround the glands and underlie the lumen; they grow, becoming progressively more convoluted, and regress again during each menstrual cycle.
VEGF: Vascular endothelial growth factor, also known as vascular permeability factor (VPF), is a protein that binds to specific endothelial cell receptors, and through them induces greatly increased microvascular permeability and new blood vessel growth (angiogenesis).
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and the significance of microvascular hyperpermeability in angiogenesis. Curr. Top. Microbiol. Immunol. 237, 97-132. Hastings, J. M., Licence, D. R., Burton, G. J., Charnock-Jones, D. S., and Smith, S. K. (2003). Soluble vascular endothelial growth factor receptor 1 inhibits edema and epithelial proliferation induced by 17beta-estradiol in the mouse uterus. Endocrinology 144(1), 326-334. This recent paper directly links estrogen-induced, VEGF-mediated edema to the subsequent growth of endometrial epithelial cells.
Dr. Koos is a Professor and Graduate Program Director in the Department of Physiology at the University of Maryland School of Medicine. His research, funded by the NICHD and NCI, focuses on the regulation of VEGF expression in the uterus and ovary by estrogen and hypoxia. He has served on numerous NIH review panels, the editorial boards of the journals Endocrinology and Biology of Reproduction, and the FASEB Board of Directors and Public Affairs Executive Committee.
Dr. Rockwell is an Assistant Professor and Director of the Biological Anthropology Research Laboratory at Temple University. Her research includes projects on ovarian function and implantation and is supported by grants from the NIH and Temple University.
Dvorak, H. F., Nagy, J. A., Feng, D., Brown, L. F., and Dvorak, A. M. (1999). Vascular permeability factor/vascular endothelial growth factor
The Vasculature of the Normal Mammary Gland: HIF-1-Independent Expansion and Regression
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This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.