Spatial Resolution of Cerebral Microvascular Blood Flow and Blood Oxygenation Changes during Neuronal Activation

During increased neuronal activity, early changes of regional CBF are more localized than later changes at time points when increased blood flow reaches the area of the draining veins. Deoxyhemoglobin concentration is larger in the venous compartment. Therefore, imaging techniques based on deoxyhemoglobin changes during the phase of hyperoxygenation are more affected by the draining vein effect than techniques using early oxyhemoglobin or regional CBF changes for brain mapping. However, as long as the mechanisms and mediators of neurovascular coupling are not known in detail, the question remains whether the area of increased blood flow exactly matches neuronally active areas of the brain or whether cerebral blood flow is controlled on a more coarse spatial scale.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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