Section V Tumors

Chemo Secrets From a Breast Cancer Survivor

Breast Cancer Survivors

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Chapter 139

Tumor Growth Patterns and

Angiogenesis 941

Cecile G. Colpaert and Peter B. Vermeulen

Growth Patterns and Angiogenesis in Primary Breast Cancer

Growth Patterns and Angiogenesis in Cutaneous Breast

Cancer Deposits Growth Patterns and Angiogenesis in Liver Metastases Growth Patterns and Angiogenesis in Primary Lung Cancer Conclusion

Chapter 140

Breast Cancer Resistance Protein in Microvessel Endothelium 947

Hiran C. Cooray and Margery A. Barrand

Introduction ABC Transporters

ABC Transporters Associated with Multidrug Resistance Tissue Distribution of BCRR Compared to Other Multidrug Transporters

Chapter 141

Tumor vs Normal Microvasculature 955

Moritz A. Konerding

Introduction and Definitions

Structural Differences between Tumor and Normal

Microvasculature Architectural Differences between Normal and Tumor Microvasculature

Chapter 137

Angiogenic Diseases of the Skin 929

Rainer Kunstfeld and Michael Detmar

Structure and Function of Cutaneous Blood Vessels Molecular Control of Skin Angiogenesis Angiogenesis in Skin Diseases

Chapter 138

Skin Microcirculation in the Elderly 933

Marco Rossi and Carlo Palombo Introduction

Skin Microcirculation in the Elderly Clinical Implications and Perspectives

Chapter 142

Endothelial Cell Heterogeneity:

Targeting the Tumor Tasculature 961

Robert R. Langley

Introduction Angiogenesis

Role of the Microenvironment and Angiogenesis Targeting Angiogenesis in Tumors Tumor Vasculogenesis Conclusion

Chapter 143 A Metronomic Approach to Antiangiogenesis 969

Raffaele Longo and Giampietro Gasparini Introduction

Metronomic Chemotherapy Experimental Sstudies Clinical Studies

Future Directions and Open Questions

Chapter 144

Platelet-Endothelial Interaction in

Tumor Angiogenesis 975

Philipp C. Manegold and Marc Dellian

Physiology of Platelet-Endothelial Interaction Platelet-Endothelial Interaction in Tumor Angiogenesis Platelets Are Potentially Involved in Tumor Angiogenesis Platelet-Endothelial Interaction Following Endothelial

Stimulation Conclusions

Chapter 145

Von Hippel-Lindau Disease: Role of

Microvasculature in Development of the Syndrome 981

David R. Mole and Peter J. Ratcliffe

The von Hippel-Lindau Hereditary Cancer Syndrome The VHL Protein (pVHL) pVHL and Oxygen Sensing Hypoxia-Inducible Factor and Angiogenesis HIF and Tumorigenesis

Chapter 146

Angiostatin Inhibits Signaling in Endothelial and Smooth-Muscle Cells 989

David C. Sane

Overview

Angiostatin: An Inhibitor of Angiogenesis

Cellular Mechanisms for the Antiangiogenic Activity of

Angiostatin Proposed Molecular Targets of Angiostatin Nontumor Effects of Angiostatin Summary

Chapter 147

Endothelial Cell Transformation by the Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus-8 993

Akrit Sodhi and J. Silvio Gutkind Introduction

Kaposi's Sarcoma: A Disease in Search of a Cause Kaposi's Sarcoma-Associated Herpesvirus (KSHV or HHV8)

KSHV Latent Genes and the Promotion of Cell

Proliferation and Survival KSHV Lytic Genes and Paracrine Neoplasia Triggering Kaposi's Sarcomagenesis Conclusion

Chapter 148

Endothelial Cells in Kawasaki Disease 999

Seiichiro Takeshita and Keigo Nakatani

Pathological Findings Immunological Abnormalities Impaired EC Function Other Findings Therapy for KD Vasculitis

Chapter 149

Response of Colon Carcinoma Cells to Proinflammatory Cytokines 1003

M. Ten Kate and C.H.J. Van Eijck Introduction

Proinflammatory Cytokines Endothelial Cells In Vitro Studies In Vivo Studies Adhesion Molecules Discussion

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