Section H Lymphatics

CHAPTER 79 Lymphatic Endothelial Cells: Heterogeneity from Blood Endothelium and Unique Properties in Health and Disease 513

J. Steven Alexander

Lymphatic versus Blood Endothelial Biology Unique Structural/Functional Markers: Lymphatic versus BEC

Junctions and Solute Barrier Function in Blood and

Lymphatic Vessels Endothelial-Cell Adhesion Molecules in BECs versus LECs

Chemokines Released by LECs and BECs Lymphatic Development

Lymphatics in Disease: Lymphedema and Cancer Summary

Chapter 80

Lymphocyte Interaction with Microvascular Endothelium 517

Sirpa Jalkanen and Marko Salmi Abstract

Physiological Lymphocyte Recirculation Inflammation-Induced Changes Molecular Events in Lymphocyte-Endothelial Cell Interaction

Importance of the Endothelial Homing-Associated Molecules

Endothelial Homing-Associated Molecules as Drug Targets

Chapter 81

The Lymphatic System 523

Michael S. Pepper

Growth and Structure of the Lymphatic Tree Lymphatic Endothelial Cells

A Renewed Perspective on the Physiopathology of the

Lymphatic System Summary and Perspectives

Chapter 82

Foundations of Microlymphatic

Function 529

Geert W. Schmid-Schonbein Introduction

Structure of Microlymphatics Lymphatic Endothelium Lymphatic Endothelial Junctions Mechanisms for Periodic Compression of Initial

Lymphatics Lymph Fluid Collection and Transport Lymphatic Fluid Pressures Lymphatic Angiogenesis Lymphatics in Tumors

Chapter 83

Morphology and Physiology of

Lymphatic Endothelial Cells 535

H. Zoltzer

Introduction History

The Endothelium of the Initial Lymphatic The Endothelium of the Precollectors The Endothelium of the Collectors and Lymphatic Stem Vessels

The Endothelium in the Lymph Nodes

Color Insert 545

_VOLUME 2_

Foreword I by Shu Chien v

Foreword II by Bruce Zetter vii

Introduction ix

Editorial Board Members xiii

Contributors xv

Section I: Pancreas Chapter 84

Pancreatic Microcirculation in

Health and Disease 547

Leif Jansson, Arne Andersson, Örjan Källskog, and Per-Ola Carlsson

Introduction Normal Pancreas

Adaptations to Functional Demands

Acute Pancreatitis

Chronic Pancreatitis

Pancreatic Cancer

Diabetes Mellitus

Conclusions

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