Section E Transport Junctions Adhesion Molecules

Chapter 46

Vesiculo-vacuolar Organelles Are Permeability Structures in the Endothelium of Normal and Tumor Microvessels 297

Ann M. Dvorak and Dian Feng Introduction

VVOs Are the Major Site of Hyperpermeability of Tumor

Blood Vessels VVO Structure VVO Function VVO Formation VVO Fate

Chapter 47

The Multistep Cascade of

Leukocyte Extravasation 303

Britta Engelhardt and Dietmar Vestweber


The Multistep Paradigm


Chapter 48

Vascular Endothelial Cadherin and Neutrophil Transmigration 309

Bastien Hermant, Marianne Weidenhaupt, St├ęphanie Heyraud, and Danielle Gulino-Debrac


Markers Expressed at Endothelial Cell-Cell Junctions Mechanism of Leukocyte Diapedesis Conclusions

Chapter 49

Vascular Gap Junctions 317

Michael Koval and Jahar Bhattacharya

Introduction Connexins

Gap Junctional Regulation

Vascular Connexin Expression

Connexins and Vascular Tone

Vascular Connexins in Pathologic Conditions


Chapter 50

Adhesion Molecules and the

Recruitment of Leukocytes in

Postcapillary Venules 321

Klaus Ley

Postcapillary Venules Leukocytes Adhesion Molecules

Physiology of Leukocyte-Endothelial Interactions Unresolved Questions

Chapter 51

Cell Adhesion Molecules: Structure, Function, Organization and Role in Leukocyte Trafficking through the Lung 327

Lina H.K. Lim and Bruce S. Bochner Introduction

General Dynamic Events Leading to Leukocyte Migration

Endothelial AMs Involved in Leukocyte Trafficking Tissue-Specific Expression of AMs in the Lung

Microvasculature Summary

Chapter 52

The Endothelium from a T-cell

Point of View 335

Federica Marelli-Berg

Regulation of T-cell Trafficking by the Endothelium Immunogenicity of the Microvascular Endothelium TCR-Dependent T-Cell Trafficking

Chapter 53

Integrins and Formation of the Microvasculature 339

Joseph H. McCarty and Richard O. Hynes Introduction

Microvascular Integrins and Their Extracellular Matrix Ligands

Interpreting the Conflicting Data

Cross-talk between Vascular Integrins and Receptor

Tyrosine Kinases The Role of the ECM in Regulating Vascular Integrin

Functions Conclusion

Chapter 54

Platelet Phospholipids Tighten the Vascular Endothelial Barrier 345

Fred L. Minnear

Platelets Support the Endothelial Barrier

Lysophosphatidic Acid (LPA)

Sphingosine 1-Phosphate (S1P)

Regulation of Vascular Endothelial Permeability and

Proposed Cellular Targets Cell-Signaling Pathways Rac and Rho

Conclusions and Future Studies

Chapter 55

Role of Gap Junctions in Capillary-Arteriolar Communication 353

Karel Tyml Introduction

Gap Junctions in the Microvasculature Evidence for Capillary-Arteriolar Communication Communication along the Microvasculature during

Sepsis Summary

Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

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