Section C Statins Chapter 153

Natural Cholesterol Guide

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Statins and the Microvasculature 1035

Reda E. Girgis and Jeffrey R. Jacobson

Introduction Mechanisms of Action Effects of Statins on the Microvasculature Statins as Antioxidants Effects on Other Vasoactive Mediators Regulation of the Endothelial Cytoskeleton by Statins Statin Effects on Vascular Wall Cell Proliferation and Survival

Anti-inflammatory Effects of Statins Antithrombotic Properties of Statins Potential Clinical Applications of Statins Targeting the

Microvasculature Pharmacokinetic Considerations Conclusion

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