Role of the Cytoskeleton in Endothelial Cell Responses

(tubulin) (actin/myosin) (vimentin)

Figure 1 Role of the Cytoskeleton in Endothelial Cell Responses. (see color insert)

(tubulin) (actin/myosin) (vimentin)

Figure 1 Role of the Cytoskeleton in Endothelial Cell Responses. (see color insert)

resultant increases in actin stress fiber formation and acto-myosin cellular contraction disrupt the barrier-regulatory balance with tethering forces and destabilize cytoskeletal-junctional linkages culminating in increased vascular permeability [1]. Direct inhibition of either MLCK or Rho kinase as well as Ca2+/calmodulin antagonism attenuates thrombin-induced MLC phosphorylation, gap formation, and barrier dysfunction as well as the increased vascular permeability observed in many but not all models of lung edema.

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Essentials of Human Physiology

Essentials of Human Physiology

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