Risk Factors for Impairment of Microvascular Repair

Risk factors for vascular disease, which include diabetes mellitus, hypercholesterolemia, and hyperhomocysteinemia, all impair angiogenesis. In turn, this can result in impaired wound healing and complications following surgery. This has been exemplified in bypass graft surgery in the preceding section. Metabolic and dietary factors, can also influence the process. For example, vitamin B6 has been shown to

Figure 4 At a higher magnification of the graft fitted with the polyester external stent (upper left panel), the presence of a highly developed microvascular system can be seen in the space between the stent and the media. It was suggested that the stent promotes this microvessel (MV) growth, which in turn provides oxygenation of the vein graft, thereby obviating hypoxia and graft thickening. The importance of microvessel formation can be seen with another kind of stent made of PTFE (upper right panel), which clearly does not promote MV formation but also does not prevent graft thickening. It has been suggested that the principal mechanism underlying this effect is that the stent concentrates an exudate (derived from the anastomotic wound) in the space between the graft and the stent (lower three panels). This exudate is rich in fibrin and leukocytes, which promotes the growth of microvessels via the classic wound-healing pathways. (see color insert)

Figure 4 At a higher magnification of the graft fitted with the polyester external stent (upper left panel), the presence of a highly developed microvascular system can be seen in the space between the stent and the media. It was suggested that the stent promotes this microvessel (MV) growth, which in turn provides oxygenation of the vein graft, thereby obviating hypoxia and graft thickening. The importance of microvessel formation can be seen with another kind of stent made of PTFE (upper right panel), which clearly does not promote MV formation but also does not prevent graft thickening. It has been suggested that the principal mechanism underlying this effect is that the stent concentrates an exudate (derived from the anastomotic wound) in the space between the graft and the stent (lower three panels). This exudate is rich in fibrin and leukocytes, which promotes the growth of microvessels via the classic wound-healing pathways. (see color insert)

inhibit angiogenesis. Interestingly, vitamin B6 controls the levels of homocysteine, an amino acid that also inhibits angiogenesis.

Diabetes Sustenance

Diabetes Sustenance

Get All The Support And Guidance You Need To Be A Success At Dealing With Diabetes The Healthy Way. This Book Is One Of The Most Valuable Resources In The World When It Comes To Learning How Nutritional Supplements Can Control Sugar Levels.

Get My Free Ebook


Post a comment