Regulation of Pghs Lox and CYP by Reactive Oxygen and Nitrogen Species

Lipid oxidation enzymes are regulated in several ways through the action of reactive oxygen and nitrogen species. In general, enzyme turnover is activated by oxidation [e.g., for LOX or PGHS by LOOH, H2O2, or peroxynitrite (ONOO")] and inhibited by reduction (e.g., nordihy-droguairetic acid and baicalein as LOX inhibitors, or removal of LOOH or H2O2 by glutathione peroxidase or catalase-dependent reduction).

Nitric oxide (NO) inhibits LOX turnover through scavenging the enzyme-bound LOO\ but exerts no direct effect on PGHS turnover in vitro. The lack of effect on PGHS turnover is intriguing since NO can interact with this enzyme

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Essentials of Human Physiology

Essentials of Human Physiology

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