Lipid oxidation enzymes are regulated in several ways through the action of reactive oxygen and nitrogen species. In general, enzyme turnover is activated by oxidation [e.g., for LOX or PGHS by LOOH, H2O2, or peroxynitrite (ONOO")] and inhibited by reduction (e.g., nordihy-droguairetic acid and baicalein as LOX inhibitors, or removal of LOOH or H2O2 by glutathione peroxidase or catalase-dependent reduction).
Nitric oxide (NO) inhibits LOX turnover through scavenging the enzyme-bound LOO\ but exerts no direct effect on PGHS turnover in vitro. The lack of effect on PGHS turnover is intriguing since NO can interact with this enzyme
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This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.