Reactive Oxygen Species and Angiogenesis

Reactive oxygen species (ROS) play a role in modulating angiogenesis. Principal among ROS are superoxide (O2-), hydrogen peroxide (H2O2), and products of the reactions between ROS and NO. Potential sources of ROS include NADPH oxidase, the mitochondrial electron transport chain, xanthine oxidase, NOS, cyclooxygenase, and lipoxy-genase. Recent studies have indicated that NADPH oxidase may be axiomatic in mediating angiogenesis. In keeping with the wound healing mechanisms described earlier, virtually all the factors that promote angiogenesis also promote the upregulation of vascular NADPH oxidase, including cytokines, peptide growth factors, angiotensin II, and TXA2. Hypoxia itself has also been shown to induce the expression of NADPH oxidase. It is of interest that copper is both a potent angiogenic factor as well as a catalyst for the generation of ROS. The mechanisms involved, however, are still obscure.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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