Histopathological studies of vascular changes in autop-sied patients with KD revealed the EC degeneration and the increased vascular permeability with edema and degeneration of the media. In the acute phase, vasculitis in subcutaneous regions begins with EC necrosis and subcutaneous edema, followed by degenerative changes in the muscle cells. Active remodeling of the coronary artery lesions (CAL) such as intimal proliferation and neoangiogenesis continues for several years after the onset of KD. Furthermore, Takahashi et al. suggest that CAL in this disease might become a risk factor for atherosclerosis of coronary arteries later in life.
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This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.