Part I


Section A: Cell Biology Chapter 1

Endothelin in the Microvasculature 5

Matthias Barton Introduction

Endothelins: Vasoactive Peptides

Regulatory Role of Endothelin for Microvascular Function Endothelin and the Microvasculature in Disease

Chapter 2

Control of Cell Motility by the Cytoskeleton and Extracellular Matrix 13

Amy Brock and Donald E. Ingber

Introduction Directional Motility The Migratory Process Control of Motility by ECM Biochemical Signaling Mechanisms Mechanical Signaling Mechanisms Future Directions

Chapter 3

Ultrastructural Morphometry of Capillary Basement Membrane Thickness 19

Edward C. Carlson Introduction

Ultrastructural Definitions

Capillary Basement Membrane Thickness in Health and Disease

Capillary Basement Membrane Morphometric Methods Conclusions

Chapter 4

IL-? Receptor and Microvascular Endothelial Cells 25

Danuta Dus, Agnieszka Krawczenko, and Claudine Kieda Receptor for IL-7

Chapter 5

Matrix Metalloproteinases, Tissue

Inhibitors of Metalloproteinases, and the Microvasculature 29

Cecilia A. Fernández and Marsha A. Moses

Matrix Metalloproteinases

Tissue Inhibitors of Metalloproteinases

Chapter ├│

Matrix Metalloproteinases and

Their Inhibitors 33

Iwona Fijalkowska and Rubin M. Tuder


Molecular Structure

Activation of Metalloproteinases

Specific Inhibitors of Metalloproteinases: TIMPs

MMP Genes and Regulation of Expression


MMPs and Pulmonary Vascular Diseases Conclusion

Chapter 7

VEGF-A and its Isoforms 41

Eric B. Finkelstein and Patricia A. D'Amore

VEGF Isoform Structure VEGF and the ECM VEGF-Receptor Interactions Isoform Expression Isoform Function Conclusion

Chapter 8

Ephrins and the Unveiling of Distinct Arterial and Venous Microcirculations 47

Jeffrey M. Gelfand and Guillermo Garcia-Cardena Introduction

Cell Signaling Via Ephrins and Eph Receptors Angiogenesis Requires Ephrin Signaling Ephrins Reveal Distinct Arterial and Venous Microvascular Identities

The Implications of a New Microvascular Paradigm

Chapter 12

Receptor Tyrosine Kinase Signal Transduction in the Microvasculature 69

Marie B. Marron and Nicholas P. J. Brindle Introduction

Signaling by VEGF Receptors Signaling by FGF Receptors The Ephs and Ephrins

Signaling by the Tie Receptor Tyrosine Kinases Conclusion

Chapter 13

Eicosanoids and the pulmonary Microvasculature 77

Ivan M. Robbins and Brian W. Christman Introduction

Pulmonary Arterial Hypertension

Clinical Modulation of Eicosanoids in Pulmonary Vascular Disease

Chapter 9

Endothelial Heterogeneity 51

Mary E. Gerritsen

Introduction Endothelial Architecture

Chapter 10 Portholes on a Vessel:

Endothelial Fenestrae 57

Sofia Ioannidou, Steven J. Samuelsson, and David T. Shima

Fenestrae Structure Fenestrae Biogenesis Fenestrae Function Challenges for the Future

Chapter 11

Neuropilins and the Vasculature 63

Roni Mamluk and Michael Klagsbrun


Neuropilin Structure

Endothelial Cell Neuropilin

Neuropilin Function in Developmental Angiogenesis

Neuropilin in Pathological Angiogenesis


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Essentials of Human Physiology

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