In addition to plasma proteins, colloidal materials (up to micrometer size) readily enter into the initial lymphatics across the primary valves. Cells the sizes of lymphocytes or of metastatic cells are carried along the lymphatics in the skin during periodic tissue compression, but not without a periodic compression of the initial lymphatics . This evidence suggests that in addition to the junctions between endothelial cells in initial lymphatics, which can open up to let micrometer-size particles pass, the lymphatic endothelium may be able to open interendothelial and transendothelial pores of a size sufficient for entire cells to migrate across. Initial lymphatics may carry lymphocytes and, under conditions of ischemia and shock, erythrocytes, platelets, and in cancer metastatic cells as well.
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This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.