Kaposis Sarcoma A Disease in Search of a Cause

The epidemiology of KS suggested an infectious etiology for this disease. As a consequence of its close association with the AIDS epidemic, initial research focus was concentrated on a newly identified virus, HIV, as the KS etiologic agent. Early work suggested that the potent transactivator HIV-1 protein, Tat, plays a major role in the pathogenesis of AIDS-related KS. Among many of its KS-promoting activities, the Tat protein augments the angiogenic activities of basic fibroblast growth factor (bFGF), interferon gamma, and vascular endothelial growth factor (VEGF); mimics the effects of the extramedullary matrix proteins fibronectin and vitronectin; and increases the expression of matrix metalloproteinases [4].

However, as KS is found in only a subpopulation of HIV-infected individuals, HIV did not appear to be sufficient for KS development. Moreover, the cause of KS in HIV-

negative individuals remained unexplained. This suggested that a second etiologic agent or cofactor might be involved in KS pathogenesis.

Delicious Diabetic Recipes

Delicious Diabetic Recipes

This brilliant guide will teach you how to cook all those delicious recipes for people who have diabetes.

Get My Free Ebook

Post a comment