Kaposis Sarcoma A Disease in Search of a Cause

The epidemiology of KS suggested an infectious etiology for this disease. As a consequence of its close association with the AIDS epidemic, initial research focus was concentrated on a newly identified virus, HIV, as the KS etiologic agent. Early work suggested that the potent transactivator HIV-1 protein, Tat, plays a major role in the pathogenesis of AIDS-related KS. Among many of its KS-promoting activities, the Tat protein augments the angiogenic activities of basic fibroblast growth factor (bFGF), interferon gamma, and vascular endothelial growth factor (VEGF); mimics the effects of the extramedullary matrix proteins fibronectin and vitronectin; and increases the expression of matrix metalloproteinases [4].

However, as KS is found in only a subpopulation of HIV-infected individuals, HIV did not appear to be sufficient for KS development. Moreover, the cause of KS in HIV-

negative individuals remained unexplained. This suggested that a second etiologic agent or cofactor might be involved in KS pathogenesis.

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Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

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