Faculty of Medicine, University François Rabelais, Tours, France
The bone marrow (BM) is the site of hematopoiesis in the adult mammal. The BM vasculature that comprises a specific structure, the sinus where exchange between BM parenchyma and circulating blood takes place, not only has a structural role, but also is actively regulating hematopoietic stem cell (HSC) self-renewal/differentiation and hematopoietic cell trafficking. The molecular mechanisms accounting for HSC homing and engraftment and for HSC mobilization from BM to blood begin to be understood. The BM vasculature contributes to the physiopathology of a number of blood neoplastic diseases.
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This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.