Hypercholesterolemia is an established risk factor for the development of cardiovascular diseases. The atherosclerotic lesions that result from a sustained elevation in blood cholesterol concentration are associated with an accumulation of inflammatory cells and platelets that facilitate the deposition of lipids in the walls of lesion-prone arteries. However, long before these changes occur in large arteries, inflammatory and prothrombogenic responses are observed in arterioles and venules throughout the vascular system (Figure 1). These responses are manifested as endothelial dysfunction and the binding of leukocytes and platelets to the vessel wall. Although several mechanisms have been proposed to explain the phenotypic changes that occur in the microvas-culature during hypercholesterolemia, oxidative stress and a diminished bioavailability of nitric oxide (NO) have gained much attention in recent years. This chapter describes the responses of the microcirculation to hypercholesterolemia and addresses the mechanism that underlies this systemic inflammatory condition.
Was this article helpful?
Discover secrets, myths, truths, lies and strategies for dealing effectively with cholesterol, now and forever! Uncover techniques, remedies and alternative for lowering your cholesterol quickly and significantly in just ONE MONTH! Find insights into the screenings, meanings and numbers involved in lowering cholesterol and the implications, consideration it has for your lifestyle and future!