A hallmark feature of hepatic inflammation is the activation of resident nonparenchymal cells, the upregulation of proinflammatory mediators, and the recruitment of leukocytes from the blood to the afflicted site. The liver is a unique organ that houses an elaborate vasculature to handle an enormous volume of blood and monitors for any pathogens that may have breached the gut wall. In this article we highlight cells and substances that mediate hepatic inflammation. We also discuss the adhesion molecules that are key for leukocyte recruitment to the liver during an inflammatory response.

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