Acute lung injury (ALI) is observed in various serious conditions such as sepsis, multiple trauma, pneumonia, and smoke inhalation. ALI is defined as a Pao2 (partial arterial oxygen pressure)/Fio2 (fractional concentration of inspired oxygen) ratio of less than 300. The decrease in Pao2/Fio2 ratio is observed because of the alveolar wall thickness (pulmonary edema) and ventilation-perfusion mismatching. The microvascular responses involve the major part of the pathophysiology [1]. In this review, we focus on the various factors that play a role in the microvascular responses associated with ALI.

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Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

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