No single cellular organizational element has commanded so much attention in the endothelial cell recently as the group of proteins known as the cytoskeleton. As depicted in Figure 1, the endothelial cytoskeleton is involved in multiple critical endothelial biologic processes including angiogenesis, mechanotransduction, apoptosis, and critical elements of the inflammatory response including leukocyte diapedisis and barrier regulation. The cytoskeleton is composed of three primary elements—actin microfilaments, intermediate filaments, and microtubules. Each will be discussed in the context of microvascular endothelial activation and dysfunction.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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