Breast Cancer Resistance Protein (BCRP) is a transporter recently identified as a member of the ATP Binding Cassette (ABC) superfamily of transmembrane proteins (discussed in the following section). It was recognized initially in several drug-resistant tumor cell lines (as discussed later) and was subsequently identified in certain tumor tissues where its presence has been putatively associated with poor clinical response to chemotherapy. However, BCRP is found on many normal, that is, nonmalignant, cells at a number of different sites in the body (see later discussion). These include endothelial cells lining various vasculature. Clues to the possible physiological role or roles of BCRP in these locations may be derived from the many studies that are now being conducted, which examine its mechanisms of action and its substrate (discussed later) and inhibitor profiles in different cell systems or that analyze its influence on the distribution of drugs in whole animals.
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This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.