Introduction

The endothelial cells (ECs) lining the walls of blood vessels in the microcirculation have a number of important functions. These include contributions to tissue structure and growth, and mediation of leukocyte recruitment from the circulation into the tissue, either for homeostasis or during inflammation. ECs can express many structures on their luminal surfaces including adhesion molecules (AMs) that are key players in leukocyte infiltration from the circulation to the tissue. This chapter will focus on the description of AMs and their ligands that mediate leukocyte-EC circulating interactions, relating to cell recruitment. Further, it will address tissue-specific expression of AMs and their related functions, particularly in the lung and pulmonary circulation [1].

Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

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