A tight temporal and spatial relationship exists among neuronal activity, metabolism, and blood flow in the brain. Changes in neuronal activity induce localized changes in metabolism and regional cerebral blood flow (rCBF), a phenomenon termed neurometabolic and neurovascular coupling. Consequently, consumption and delivery of oxygen and glucose, the metabolic substrates that fuel the brain, change at the same time. Different temporal and spatial kinetics of oxygen consumption and blood flow lead to complex changes in regional cerebral blood oxygenation. This chapter presents a detailed description of the dynamic changes of blood flow and blood oxygenation during functional activation and relates these to our current knowledge on activation-induced changes of oxygen metabolism in the brain.
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This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.