Microvascular permeability is a collective phrase to describe the barrier properties of microvascular walls in terms of the ease with which fluid and solute molecules are transported between blood and tissues. The higher the microvascular permeability to a particular solute, the lower the barrier of the microvascular walls to that solute.
Permeability is measured quantitatively in terms of permeability coefficients whose values are determined by the properties of pathways through the endothelium. In many experimental studies, changes in permeability are inferred from changes in solute transport from blood to tissues. When this is done the results should be examined critically, because several factors in addition to permeability may influence blood tissue transport. Only changes in the permeability coefficients yield information that may be interpreted unambiguously in terms of changes in permeability.
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This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.