In Vitro Models of the Human Blood Brain Barrier

The main goals of in vitro studies of the blood-brain barrier are to reproduce as many aspects of the physiology and biology of the BBB in vivo as possible and to understand human disease. Therefore, it is imperative to stress the need for human cell-based models since several pathological conditions cannot be reproduced in cell-line-derived or rodent-based BBB models.

The current understanding of brain pathophysiology has led to the hypothesis that numerous diseases of the CNS are associated with failure of BBB structural integrity or function, as an altered BBB permeability may be observed in several diseases—epilepsy, ischemia, trauma, etc.

Extravasation of plasma proteins with BBB dysfunction can occur through any number of different transcellular or paracellular routes, including altered tight junctions, disruption of EC membranes, or formation of transendothelial channels. These pathways, however, are not mutually exclusive. Regardless of whether BBB disruption or consequences of the disease(s) themselves are the main factors leading to dysfunction or changes in structural integrity, the understanding of the mechanisms of the BBB is limited. This is perhaps due to the lack of comprehensive BBB models.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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