Figure 2 Integrin signaling cascades during angiogenesis. Various integrins, extracellular matrix proteins, and receptor tyrosine kinases with roles in endothelial cell function are shown. Pink lettering indicates endogenous inhibitors of integrin-mediated angiogenesis. Orange lettering indicates blocking antibodies or peptide antagonists that inhibit integrin function. Lines with double-headed arrows indicate direct physical connections between proteins. Double-headed ball-ended lines denote signaling cross-talk between receptors. (see color insert)
dation of the proangiogenic factor fibronectin generates the angiogenesis inhibitor anastelin.
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