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Figure 2 Integrin signaling cascades during angiogenesis. Various integrins, extracellular matrix proteins, and receptor tyrosine kinases with roles in endothelial cell function are shown. Pink lettering indicates endogenous inhibitors of integrin-mediated angiogenesis. Orange lettering indicates blocking antibodies or peptide antagonists that inhibit integrin function. Lines with double-headed arrows indicate direct physical connections between proteins. Double-headed ball-ended lines denote signaling cross-talk between receptors. (see color insert)

dation of the proangiogenic factor fibronectin generates the angiogenesis inhibitor anastelin.

Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

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