In patients with diabetes, glycosylated hemoglobin is generally considered the best parameter to detect the individual risk for the development of long-term vascular complications. The multicenter, randomized, prospective Diabetes Control and Complications Trial (DCCT) con firmed previous studies demonstrating glycemic control to be the most important predictor for the development and severity of complications in T1DM. In patients with T1DM more severe endothelial dysfunction is present when they have poor glycemic control compared with patients with better glycosylated hemoglobin. There is evidence that vasodilatation mediated by endothelium-derived NO is altered in patients with both T1DM and T2DM DM. Moreover, impaired NO-mediated vasodilatation during acute hyperglycemia has been documented in nondiabetic humans. Other studies, however, were not able to demonstrate a correlation between HbA1c values and degree of endothelium-dependent vasodilatation.
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This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.