Research has established the important role VEGF plays in the development of the embryonic vascular system, in angiogenesis, and in maintaining or augmenting endothelial functions in the adult vasculature. Both positive and negative regulation of endothelial cells by VEGF can be critical for the maintenance of the vascular system.
Future research needs to concentrate on the mechanisms through which VEGF induces its effects. Research has to clarify the effect of VEGF on gene expression, the interactions between different signaling pathways in the regulation of endothelial cells, and their integration within the cell. Firmly establishing the functions of VEGF could help advance research on the use of VEGF for endothelial and
Dr. Kanyarat Suthin is head of Periodontology at the Faculty of Dentistry, Prince of Songkla University, Thailand, and her research focus is on pathogenesis and tissue regeneration. Her work is supported by grants from the Ministry of Education, Science, Sports and Culture of Japan.
Dr. Miho Machigashira is a assistant professor of the Department of Periodontology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan, and her research focus is on periodon-tal pathogens and the role and mechanism of hepatocyte growth factor (HGF) in periodontal regeneration. Her work is supported by grants from the Japan Society for the Promotion of Science.
Prof. Yuichi Izumi has headed the Department of Periodontology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan, since 1999. He has numerous publications in the area of pathogenesis and regeneration in periodontology, and his work is supported by numerous grants from the Ministry of Education, Science, Sports and Culture of Japan.
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This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.