Imperial College, London
Lymphocyte recirculation and the localized recruitment of antigen-specific T cells to sites of inflammation are critical to the surveillance and effector functions of the immune system. A tightly regulated series of molecular interactions with the microvascular endothelium (extravasation) allows T lymphocytes to continuously recirculate from the bloodstream into lymphoid and nonlymphoid tissue scanning for their cognate antigen. During these frequent encounters the endothelium itself has the opportunity to display antigen to transiting T lymphocytes with the potential to modify their functions.
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