Endothelial Cells in Kawasaki Disease

1Seiichiro Takeshita and 2Keigo Nakatani

1Ibaraki University, Faculty of Education 2Kobayashi City Hospital

Kawasaki disease (KD) is an acute febrile illness that affects predominantly infants and children. Although its etiology remains unknown, KD is characterized as one type of multisystemic vasculitis. This disease leads to the activation and injury of endothelial cells (ECs) in the acute phase. The most critical complication of KD is the coronary artery aneurysm that may lead to myocardial infarction. KD patients have structural, immunological, and functional abnormalities of ECs (Table I).

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