Embryonic Angiogenesis

VEGF can affect the process of embryonic angiogenesis in addition to its roles in vasculogenesis described previously. The effect of VEGF on angiogenesis has been examined in the mouse eye, where the retinal vasculature expands by sprouting as the retina grows [8]. The vascular sprout contains two types of endothelial cells: tip cells and stalk cells, which can be distinguished by differences in gene expression and morphology [9]. Filopodia of tip cells direct cell migration by sensing a gradient of VEGF, while stalk cells respond to VEGF by proliferation. VEGF induces filopodia to extend from tip cells, which are guided toward VEGF sources. VEGF antagonists inhibit these activities. This is similar to the protrusive activity of endothelial cells in the developing quail embryo, as disruption of VEGF gradients inhibits protrusive activity and migration of sprouting tip cells.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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